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KMID : 0613820060160071169
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Journal of Life Science
2006 Volume.16 No. 7 p.1169 ~ p.1173
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Effects of Ulva lactuca Extracts on Cytotoxicity of Cancer Cell Lines and Immune Stimulation
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Jang Min-Kyung
Kim Nam-Young
Lee Dong-Geun
Lee Jae-Hwa
Ha Jong-Myung
Ha Bae-Jin
Kim Mi-Hyang
Bae Song-Ja
Jang Jeong-Su
Lee Sang-Hyeon
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Abstract
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Extracted fractions of the green seaweed Ulva lactuca were studied to verify the cytotoxicity and immunostimulating activity. The fractions from the ethanol extract of U. lactuca were prepared by the systematic extraction procedure with solvents such as hexane, ethyl ether, methanol, butanol and H2O. The cytotoxic effects of U. lactuca fractions against human leukemia cell line U937, mouse neuroblastoma cell line (NB41A3), human hepatoma cell line (HepG2) and rat glioma cell line (C6) were investigated. Ethyl ether fraction showed the highest cytotoxicity against all four cell lines tested. In addition, H2O fraction also showed relatively high cytotoxicity. Dose dependent patterns were observed on all four cell lines. The immuno-stimulating effects of U. lactuca fractions on rat macrophage cell line (RAW 264.7) were also investigated. All five fractions of U. lactuca extract stimulated NO production with concentration dependant manner. These results suggest that U. lactuca may be a useful candidate for a natural cancer preventing and immuno-stimulating agents.
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KEYWORD
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C6, HepG2, MTT assay, NB41A3, NO assay, RAW 264.7, U937, Ulva lactuca
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